Research

 

Schematic of microbiome research in the Staley/Jahansouz lab
Overview of research. Image created with Biorender.com

Research Projects

We collaborate with a wide variety of highly motivated physician and basic scientists, and our on-going research projects include:

The Microbiome in Surgical Healing

  • Characterizing changes in the microbiome associated with surgery and peri-operative antibiotics
  • Evaluating oral translocation of bacteria (and opportunistic pathogens) in the acute peri-operative period.
  • Determining mechanistic roles of the microbiota in surgical outcomes using mouse models

Quorum Quenching Studies

  • Evaluate the in vivo effects of quorum quenching lactonases on microbiota composition and function
  • Determine efficacy of quorum quenching to mitigate pathological processes in colorectal cancers