Staley/Jahansouz Lab

Staley lab

Microbiome Analytics

The gut microbiota, characterized as the microbiome, plays a pivotal role in human health, function, and disease. Our primary research focus is to characterize patterns in microbiome imbalance, called dysbioses, that affect the onset and progression of diseases. We use next-generation sequencing, metagenomics approaches, ecological principles, and translational mouse models to fully understand shifts in microbial community composition, organization, and function in the hopes of developing personalized, microbiota-based therapeutics and practices. Current major and overlapping areas of study include:

1. Optimizing a human microbiota-associated (HMA) mouse model for preclinical, translational studies and to explore microbial resilience.

2. Assessing changes and mechanisms of the gut microbiota associated with surgery and surgical outcomes.

3. Evaluating the efficacy of disrupting quorum signaling as a targetable microbiota therapeutic approach.






Apr 2024

Apr 1: Official role out of our ISO core. We have also added instructions our group uses to help navigate the supercomputers and manage data.

Mar 2024

Mar 4: Our paper Long- and short-term effects of fecal microbiota transplantation on antibiotic resistance genes: results from a randomized placebo-controlled trial was accepted in Gut Microbes!

Jan 2024

Jan 22: Our manuscript Effect of ginger supplementation on the fecal microbiome in subjects with prior colorectal adenoma has been accepted in Scientific Reports!

Nov 2023

Nov 9: Our manuscript Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery was accepted in Gut Microbes!

Sep 2023

Sep 25: Our manuscript Potential of fecal microbiota transplantation to prevent acute graft-versus-host disease: Analysis from a phase 2 trial has been accepted in Clinical Cancer Research.

Aug 2023

Aug 29: Our paper Temporal Variation in Oral Microbiome Composition of Patients Undergoing Autologous Hematopoietic Cell Transplantation with Keratinocyte Growth Factor was accepted in BMC Microbiology!