Staley/Jahansouz Lab

Staley lab

Microbiome Analytics

The gut microbiota, characterized as the microbiome, plays a pivotal role in human health, function, and disease. Our primary research focus is to characterize patterns in microbiome imbalance, called dysbioses, that affect the onset and progression of diseases. We use next-generation sequencing, metagenomics approaches, ecological principles, and translational mouse models to fully understand shifts in microbial community composition, organization, and function in the hopes of developing personalized, microbiota-based therapeutics and practices. Current major and overlapping areas of study include:

1. Optimizing a human microbiota-associated (HMA) mouse model for preclinical, translational studies and to explore microbial resilience.

2. Assessing changes and mechanisms of the gut microbiota associated with surgery and surgical outcomes.

3. Evaluating the efficacy of disrupting quorum signaling as a targetable microbiota therapeutic approach.

 

 

 

Tags

News


Aug 2023
Aug 2023

Aug 29: Our paper Temporal Variation in Oral Microbiome Composition of Patients Undergoing Autologous Hematopoietic Cell Transplantation with Keratinocyte Growth Factor was accepted in BMC Microbiology!

Jul 2023
Jul 2023

Jul 10: Welcome Aneesh as our new researcher 1!

Jun 2023
Jun 2023

Jun 22: Welcome Zachary as our new undergraduate researcher!

Apr 2023
Apr 2023

Apr 14: Our paper A Randomized Double-Blind Phase 2 Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and Acute Myeloid Leukemia has been accepted in the Journal of Clinical Oncology.

Apr 12: Our paper with the Subree lab Fecal Microbiota Restoration Modulates the Microbiome in Inflammation-Driven Colorectal Cancer has been published in Cancers.

Mar 2023
Mar 2023

Mar 17: Congrats, Tom! He's matched with our GI/research residency program!

Mar 2: We'll see you at ASM! Maria and Matt's abstracts were both accepted.

Jan 2023
Jan 2023

Jan 28: Congratulations to Cyrus for being named one of Minneapolis/St. Paul Top Doctors: Rising Stars.

Jan 26: Major webpage updates underway.

Dec 2022
Dec 2022

Dec 19: Congratulations, Matt! He was awarded a Minnesota Colorectal Cancer Research Foundation award for his project Quorum Quenching Enzymes Effect on Oncogenesis and Bacterial Signaling.

Oct 2022
Oct 2022

Oct 6: Congratulations to Maria for winning 2nd place for her poster at Surgery Research Week!

Jul 2022
Jul 2022

Jul 27: Our paper Fecal β-glucuronidase Activity Differs between Hematopoietic Cell and Kidney Transplantation and a Possible Mechanism for Disparate Dose Requirements has been accepted in Gut Microbes!

Jul 26: Our paper Compilation of Longitudinal Gut Microbiome, Serum Metabolome, and Clinical Data in Acute Myeloid Leukemia has been accepted in Scientific Data!