Staley Lab

Staley lab

Please join us for the next meeting of the UMN Microbiota Supergroup April 28 from 3-4pm!

Microbiome Analytics

The gut microbiota, characterized as the microbiome, plays a pivotal role in human health, function, and disease. Our primary research focus is to characterize patterns in microbiome imbalance, called dysbioses, that affect the onset and progression of diseases. We use next-generation sequencing, metagenomics approaches, ecological principles, and translational mouse models to fully understand shifts in microbial community composition, organization, and function in the hopes of developing personalized, microbiota-based therapeutics and practices. Current areas of study include:

1. Determining the role of the microbiome in the onset and progression of obesity.

2. Characterizing shifts in gut microbiota related to intestinal damage during chemotherapy for acute leukemia and bone marrow transplant.

3. Evaluating the microbiome-tumor interactions in colorectal cancers.

4. Developing encapsulated microbial preparations to treat recurrent Clostridium difficile infections and other conditions.



Apr 2021

Apr 5: Hossam received the 2021 Donald R. Zander Alumni Award for Outstanding Student Leadership.

Apr 1: Please welcome our new undergrad Maria! Also, congratulations to Hossam for being selected as a 2021 Pathways to Research Program Scholar!

Mar 2021

Mar 15: Welcome new lab members Rubayat (post-doc) and Nirupa (undergrad)!

Mar 22: Hossam was awarded the President’s Student Leadership & Service Award!

Feb 2021

Feb 11: Our paper Lower Endoscopic Delivery of Freeze-Dried Intestinal Microbiota Results in More Rapid and Efficient Engraftment Than Oral Administration has been accepted in Scientific Reports.

Jan 2021

Jan 4: Our paper Donor Microbiota Composition and Housing Affect Recapitulation of Obese Phenotypes in a Human Microbiota-Associated Murine Model was accepted to Frontiers in Cellular and Infection Microbiology.

Nov 2020

Nov 9: Our paper Peri-operative Antibiotics Acutely and Significantly Impact Intestinal Microbiota Following Bariatric Surgery was accepted in Scientific Reports.