Staley/Jahansouz Lab

Staley lab

Microbiome Analytics

The gut microbiota, characterized as the microbiome, plays a pivotal role in human health, function, and disease. Our primary research focus is to characterize patterns in microbiome imbalance, called dysbioses, that affect the onset and progression of diseases. We use next-generation sequencing, metagenomics approaches, ecological principles, and translational mouse models to fully understand shifts in microbial community composition, organization, and function in the hopes of developing personalized, microbiota-based therapeutics and practices. Current areas of study include:

1. Determining the role of the microbiome in the onset and progression of obesity.

2. Assessing changes and mechanisms of the gut microbiota associated with surgery and surgical outcomes.

3. Characterizing shifts in gut microbiota related to intestinal damage during chemotherapy for acute leukemia and bone marrow transplant.

4. Evaluating the microbiome-tumor interactions in colorectal cancers.

5. Developing encapsulated microbial preparations to treat recurrent Clostridium difficile infections and other conditions.

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News


Jul 2022

Jul 27: Our paper Fecal β-glucuronidase Activity Differs between Hematopoietic Cell and Kidney Transplantation and a Possible Mechanism for Disparate Dose Requirements has been accepted in Gut Microbes!

Jul 26: Our paper Compilation of Longitudinal Gut Microbiome, Serum Metabolome, and Clinical Data in Acute Myeloid Leukemia has been accepted in Scientific Data!

Jun 2022

Jun 13: Our paper A Pilot Study Demonstrating the Impact of Surgical Bowel Preparation on Intestinal Microbiota Composition Following Colon and Rectal Surgery has been accepted in Scientific Reports.

Jun 4: Congratulations, Hossam! He has been accepted to Med School class of 2026 at UMN!

Jun 2: Our paper A Dose-Finding Safety and Feasibility Study of Oral Activated Charcoal and its Effects on the Gut Microbiota in Healthy Volunteers not Receiving Antibiotics has been accepted in PLOS ONE (after 54 weeks under review).

Apr 2022

Apr 20: Our paper Reduced Enterohepatic Recirculation of Mycophenolate and Lower Blood Concentrations are Associated with the Stool Bacterial Microbiome After Hematopoietic Cell Transplantation has been accepted in Transplantation and Cellular Therapy.

Apr 12: Our paper Intestinal Blautia may protect against neutropenic fever in allogeneic transplant patients by augmenting the intestinal epithelium has been accepted in Clinical Infectious Diseases

Apr 5: Our paper Loss of microbiota-derived protective metabolites after neutropenic fever has been accepted in Scientific Reports.

Mar 2022

Mar 11: Our review Network-based Approaches for Investigation of Microbial Community Structure and Function Using Metagenomics-based Data was accepted in Future Microbiology.

Feb 2022

Feb 16: Our papers Lasting shift in the gut microbiota in patients with acute myeloid leukemia and Encapsulated fecal microbiota transplantation: development, efficacy, and clinical application were accepted in Blood Advances and Frontiers in Cellular and Infection Microbiology, respectively.

Dec 2021

Dec 22: Congratulations to Sonja! She received a General Surgery Resident Research Initiation Grant from the American Society of Colon and Rectal Surgeons.